Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: new dopamine transporter inhibitors |
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| Authors: | Tamiz A P Smith M P Enyedy I Flippen-Anderson J Zhang M Johnson K M Kozikowski A P |
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| Affiliation: | Drug Discovery Program, Department of Neurology, Georgetown University Medical Center, Washington, DC 20007-2197, USA. |
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| Abstract: | 
The synthesis and biological activity of a series of 6-substituted 1-azabicyclo[3.2.1]octanes are described. 1-Azabicyclo[3.2.1]octanes represent a new class of compounds that exhibit monoamine transporter inhibitory activity highly dependent on the overall topology and the absolute stereochemistry of the molecule. |
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