| 血流剪切力在动脉粥样硬化形成中的作用 |
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| 作者姓名： | Tang ZH Wang NP Shu C |
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| 作者单位： | 1. 北京大学心血管研究所,分子心血管学教育部重点实验室,北京,100083
2. 美国加州大学圣地亚戈分校医学与生物工程学系,圣地亚戈,92093 |
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| 基金项目： | 国家自然科学基金;教育部创新团队发展基金 |
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| 摘 要： | 血管内皮位于血管壁和血液的界面,直接与血流接触而持续受血流剪切力的作用。血管内皮细胞能感受血流机械力的变化,通过激活相应的信号通路调节血管内皮和平滑肌的结构和功能。研究发现,血液流动力的形式与动脉粥样硬化的发生发展有密切的关系。本综述将就血流剪切力与动脉粥样硬化的相互关系及作用机制的最新研究进展作简要介绍。
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| 关 键 词： | 剪切力 血管内皮 信号转导 动脉粥样硬化 |
Roles of shear stress in atherogenesis |
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| Tang ZH,Wang NP,Shu C.Roles of shear stress in atherogenesis[J].Progress in Physiological Sciences,2007,38(1):37-42. |
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| Authors: | Tang Zhi-Hui Wang Nan-Ping Shu Chien |
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| Institution: | 1 Institution of Cardiovascular Science,Peking University ,Key Laboratory of Molecular Cardiovascular Sciences ,Ministry of Education, Seijing 100083, China; 2Departments of Bioengineering and Medicine, University of California, San Diego, California 92093, USA |
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| Abstract: | Located between circulating blood and vessel wall, vascular endothelial cells (ECs) are constantly exposed to shear stress resulting from blood flow. The mechanical actions of shear stress can be detected by mechanosensors on ECs and converted into specific signaling pathways to mediate the structural and functional remodeling. Patterns of shear stress may contribute to the focal distribution of atherosclerotic lesions. Here, we review recent advances regarding the roles of shear stress in atherogenesis. |
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| Keywords: | shear stress endothelium signal transduction atherosclerosis |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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