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Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates
Authors:David Gallo  TaeHyung Kim  Barnabas Szakal  Xanita Saayman  Ashrut Narula  Yoona Park  Dana Branzei  Zhaolei Zhang  Grant W. Brown
Affiliation:1. Department of Biochemistry, University of Toronto, 1 King’s College Circle, Toronto, ON M5S 3E1, Canada;2. Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada;3. Department of Computer Science, University of Toronto, 1 King’s College Circle, Toronto, ON M5S 3E1, Canada;4. IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy;5. Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, 27100 Pavia, Italy
Abstract:
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  • Keywords:DNA replication  replication stress  translesion synthesis  post-replication repair  ubiquitination  single-stranded DNA  mutagenesis
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