Cyanamide mediated syntheses under plausible primitive earth conditions |
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Authors: | E Sherwood J Oró |
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Institution: | (1) Departments of Biophysical Sciences and Chemistry, University of Houston, 77004 Houston, Texas, USA |
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Abstract: | Summary When an aqueous solution (pH 7.0) of deoxythymidine 5-phosphate, 4-amino-5-imidazolecarboxamide and cyanamide was dried and heated for 18 h at 60°C, P1, P2-dideoxythymidine 5-pyrophosphate (I) was formed in a 58% yield. Oligonucleotides were not detected in the reaction product. Under conditions employed in the above reaction, (I) was shown to be stable. In prebiotic polymerization reactions employing deoxythymidine 5-triphosphate as the polymerizing species, (I) could therefore function as a primer and minimize the formation of cyclic nucleotides.Abbreviations dT
deoxythymidine
- dTMP
deoxythymidine 5-phosphate
- dTppT
P1, P2-dideoxythymidine 5-pyrophosphate
- dTTP
deoxythymidine 5-triphosphate
- AICA
4-amino-5-imidazolecarboxamide |
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Keywords: | Prebiotic Polymerization Deoxythymidine oligonucleotides Deoxythymidine 5-monophosphate" target="_blank">gif" alt="prime" align="BASELINE" BORDER="0">-monophosphate P1 P2-dideoxythymidine 5-pyrophosphate" target="_blank">gif" alt="prime" align="BASELINE" BORDER="0">-pyrophosphate 4-amino-5-imidazolecarboxamide Cyanamide |
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