Anti-Trypanosoma cruzi and cytotoxic activities of Eugenia uniflora L |
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Authors: | Santos Karla K A Matias Edinardo F F Tintino Saulo R Souza Celestina E S Braga Maria F B M Guedes Gláucia M M Rolón Miriam Vega Celeste de Arias Antonieta Rojas Costa José G M Menezes Irwin R A Coutinho Henrique D M |
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Institution: | Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato, CE, Brazil. |
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Abstract: | Chagas disease is caused by Trypanosoma cruzi, being considered a public health problem. An alternative to combat this pathogen is the use of natural products isolated from fruits such as Eugenia uniflora, a plant used by traditional communities as food and medicine due to its antimicrobial and biological activities. Ethanolic extract from E. uniflora was used to evaluate in vitro anti-epimastigote and cytotoxic activity. This is the first record of anti-Trypanosoma activity of E. uniflora, demonstrating that a concentration presenting 50% of activity (EC(50)) was 62.76 μg/mL. Minimum inhibitory concentration (MIC) was ≤ 1024 μg/mL. Our results indicate that E. uniflora could be a source of plant-derived natural products with anti-epimastigote activity with low toxicity. |
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