Genetic differences in nicotine-induced conditioned taste aversion |
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| Institution: | 1. School of Civil Engineering, Chongqing University, No.83 Shabei Street, Chongqing 400045, China;2. School of Qilu Transportation, Shandong University, 12550 East Second Ring Road, Jinan 250002, China;3. College Civil Engineering and Architecture, Research Center of Coastal and Urban, Geotechnical Engineering, Zhejiang University, 310058, China;1. Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (Northeast Region), Ministry of Agriculture and Rural Affairs/ Northeast Agricultural University, Harbin, 150030, China;2. College of Horticulture and Landscape, Northeast Agricultural University, Heilongjiang, Harbin, 150030, China;3. Vegetable Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China |
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| Abstract: | Genetic differences in nicotine-induced conditioned taste aversion were examined using inbred mice. Adult male C57BL/6J, DBA/2J, BALB/cJ and C3H/heJ mice were adapted to a 2-h per day water access regimen. Subsequently, mice received nicotine injections (0.5, 1.0 or 2.0 mg/kg) immediately after 1-h access to a NaCl flavored solution. DBA and C3H mice developed dosedependent aversions to the nicotine-paired flavor. BALB mice showed only minor reductions in intake with no difference between the nicotine dose groups. C57BL mice did not show development of nicotine-induced conditioned taste aversion. These results demonstrate that nicotine's aversive motivational effect is strongly influenced by genotype. Further, genetic sensitivity (DBA mice) or insensitivity (C57BL mice) to nicotine-induced conditioned taste aversion was similar to reports of genetic sensitivity to ethanol's aversive effect measured in this design. |
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