A time to fast,a time to feast: The crosstalk between metabolism and the circadian clock |
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Authors: | Judit Kovac Jana Husse Henrik Oster |
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Institution: | 1.Circadian Rhythms Group,Max Planck Institute of Biophysical Chemistry,G?ttingen,Germany;2.Genes and Behaviour Department,Max Planck Institute of Biophysical Chemistry,G?ttingen,Germany |
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Abstract: | The cyclic environmental conditions brought about by the 24 h rotation of the earth have allowed the evolution of endogenous
circadian clocks that control the temporal alignment of behaviour and physiology, including the uptake and processing of nutrients.
Both metabolic and circadian regulatory systems are built upon a complex feedback network connecting centres of the central
nervous system and different peripheral tissues. Emerging evidence suggests that circadian clock function is closely linked
to metabolic homeostasis and that rhythm disruption can contribute to the development of metabolic disease. At the same time,
metabolic processes feed back into the circadian clock, affecting clock gene expression and timing of behaviour. In this review,
we summarize the experimental evidence for this bimodal interaction, with a focus on the molecular mechanisms mediating this
exchange, and outline the implications for clock-based and metabolic diseases. |
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