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Kaurane diterpenes from Sideritis spp. exert a cytoprotective effect against oxidative injury that is associated with modulation of the Nrf2 system
Institution:1. Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, University Moulay Ismail, Meknes, Morocco;2. Separation Process Laboratories, Faculty of Science, University Ibn Tofail, Kenitra, Morocco;3. ESTM, University Moulay Ismail, Meknes, Morocco;1. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;2. A. N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russian Federation
Abstract:
Keywords:Kaurane diterpenes  Oxidative stress  Hydrogen peroxide  PC12 cells  CAT"}  {"#name":"keyword"  "$":{"id":"k0035"}  "$$":[{"#name":"text"  "_":"catalase  DCFH-DA"}  {"#name":"keyword"  "$":{"id":"k0045"}  "$$":[{"#name":"text"  "_":"2′  7′-dichlorofluorescin diacetate  DMSO"}  {"#name":"keyword"  "$":{"id":"k0055"}  "$$":[{"#name":"text"  "_":"dimethylsulfoxide  GPx"}  {"#name":"keyword"  "$":{"id":"k0150"}  "$$":[{"#name":"text"  "_":"glutathione peroxidase  GR"}  {"#name":"keyword"  "$":{"id":"k0070"}  "$$":[{"#name":"text"  "_":"glutathione reductase  GSH"}  {"#name":"keyword"  "$":{"id":"k0080"}  "$$":[{"#name":"text"  "_":"glutathione  GSSG"}  {"#name":"keyword"  "$":{"id":"k0090"}  "$$":[{"#name":"text"  "_":"oxidized glutathione  HO-1"}  {"#name":"keyword"  "$":{"id":"k0100"}  "$$":[{"#name":"text"  "_":"hemeoxygenase-1  MTT"}  {"#name":"keyword"  "$":{"id":"k0110"}  "$$":[{"#name":"text"  "_":"3-(4  5-dimethylthiazol-2-yl)-2  5-diphenyl-tetrazolium bromide  Nrf2"}  {"#name":"keyword"  "$":{"id":"k0120"}  "$$":[{"#name":"text"  "_":"nuclear factor-erythroid 2  ROS"}  {"#name":"keyword"  "$":{"id":"k0130"}  "$$":[{"#name":"text"  "_":"reactive oxygen species  SOD"}  {"#name":"keyword"  "$":{"id":"k0140"}  "$$":[{"#name":"text"  "_":"superoxide dismutase
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