Lupane,friedelane, oleanane,and ursane triterpenes from the stem of Siphonodon celastrineus Griff |
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Institution: | 1. Department of Chemistry and Biochemistry, Old Dominion University, VA, USA, 23529;2. Canadian Light Source Far-Infrared Beamline, 44 Innovation Blvd, Saskatoon, Canada SK S7N 2V3 |
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Abstract: | Twenty-one triterpenes consisting of a lupane derivative, two friedelanes, an oleanane derivative, and 17 ursane-type triterpenoids, together with three known triterpenes, three sterols, a fatty acid, a sesquiterpene alkaloid, and a glycerol derivative, were isolated from the stem of Siphonodon celastrineus. Their structures were characterized by various spectroscopic techniques, as well as comparison with literature data. Twenty-seven metabolites of these were evaluated for cytotoxic activity against six human cancer cell lines. The biosynthetic formation of a 1,4-dioxane bridge is also discussed. |
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Keywords: | Celastraceae Lupanes Friedelanes Oleananes Ursanes Triterpenes NMR spectroscopy Cytotoxic activities |
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