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5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors |
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| Authors: | Angibaud Patrick Bourdrez Xavier Devine Ann End David W Freyne Eddy Ligny Yannick Muller Philippe Mannens Geert Pilatte Isabelle Poncelet Virginie Skrzat Stacy Smets Gerda Van Dun Jacky Van Remoortere Pieter Venet Marc Wouters Walter |
| Affiliation: | Medicinal Chemistry Department, Johnson & Johnson Pharmaceutical Research & Development, Campus de Maigremont BP615, 27106 Val de Reuil, France. pangibau@prdfr.jnj.com |
| Abstract: | The evaluation of structure-activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described. |
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