Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic |
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| Authors: | Shafagh Al Nadaf Paul D Waters Edda Koina Janine E Deakin Kristen S Jordan Jennifer AM Graves |
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| Institution: | (1) Research School of Biology, The Australian National University, Biology Place, Canberra, 0200, Australia;(2) ARC Centre of Excellence for Kangaroo Genomics, Research School of Biology, The Australian National University, Biology Place, Canberra, 0200, Australia;(3) Current address: Cytogenetics Department, ACT Pathology, The Canberra Hospital, Yamba Drive, Canberra, 2605, Australia |
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| Abstract: | Background X chromosome inactivation is a spectacular example of epigenetic silencing. In order to deduce how this complex system evolved,
we examined X inactivation in a model marsupial, the tammar wallaby (Macropus eugenii). In marsupials, X inactivation is known to be paternal, incomplete and tissue-specific, and occurs in the absence of an
XIST orthologue. |
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