Mitochondrial DNA heteroplasmy in ovine fetuses and sheep cloned by somatic cell nuclear transfer |
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| Authors: | Jörg P Burgstaller Pamela Schinogl Andras Dinnyes Mathias Müller Ralf Steinborn |
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| Institution: | 1.Institute of Animal Breeding and Genetics,University of Veterinary Medicine,Vienna,Austria;2.Szent István University,G?d?ll?,Hungary;3.Agricultural Biotechnology Center, Genetic Reprogramming Group,G?d?ll?,Hungary |
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| Abstract: | Background The mitochondrial DNA (mtDNA) of the cloned sheep "Dolly" and nine other ovine clones produced by somatic cell nuclear transfer
(SCNT) was reported to consist only of recipient oocyte mtDNA without any detectable mtDNA contribution from the nucleus donor
cell. In cattle, mouse and pig several or most of the clones showed transmission of nuclear donor mtDNA resulting in mitochondrial
heteroplasmy. To clarify the discrepant transmission pattern of donor mtDNA in sheep clones we analysed the mtDNA composition
of seven fetuses and five lambs cloned from fetal fibroblasts. |
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