Prolongation of Life in Anephric Rats following de novo Renal Organogenesis |
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| Authors: | Erica G. Tierney Garry P. Duffy Sally-Ann Cryan Caroline M. Curtin Fergal J. O’Brien |
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| Affiliation: | 1.Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland.;2.Trinity Centre for Bioengineering, Trinity College, Dublin, Ireland.;3.School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland. |
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| Abstract: | ![]()
One solution to the shortage of human organs available for transplantation envisions growing new organs in situ. This can be accomplished by transplantation of developing organ anlagen/primordia. Allotransplantation of embryonic day 15 metanephroi into the omentum of adult hosts is followed by differentiation, growth, vascularization and function of the implants. Here we show that survival of rats with all native renal mass removed can be increased by prior metanephros transplantation and ureteroureterostomy. Excretion of urine formed by metanephroi is prerequisite for enhanced survival. This is the first demonstration that life can be extended following de novo renal organogenesis. |
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| Keywords: | 3-D images 3-D printing development organogenesis sterolithography tissue culture |
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