A Simple and Stable Silica Gel Support for the Oligodeoxyribonucleotide Synthesis |
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| Authors: | Joseph Deutsch Sason Cohen Moshe Weisz Jehoshua Katzhendler |
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| Affiliation: | Department of Pharmaceutical Chemistry , The Hebrew University of Jerusalem School of Pharmacy , Jerusalem, Israel |
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| Abstract: | ![]()
Abstract A simple and efficient synthesis of a solid support with a long chain polyamide spacer has been developed. The spacer was made by successive addition of ethylene-diamine and succinic anhydride. The obtained solid support gives very homogeneous 20 mer oligodeoxyribonucleotides, detected by HPLC and electrophoresis. |
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| Keywords: | MAOS MWI 1,2,4-Triazoles Acyclonucleosides Seco C-Nucleosides |
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