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Superactive Oligonucleotide Derivatives |
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| Authors: | D. S. Sergeyev P. E. Vorobjev V. F. Zarytova |
| Affiliation: | Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of RAS , Novosibirsk, 630090, Russia |
| Abstract: | Abstract The conjugate of antitumor antibiotic bleomycin A5 with the tetranucleotide catalytically cleaves 20-mer ssDNA target in the presence of flanking octanucleotides. Each molecule of the conjugate cleaves on the average three molecules of the target. |
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