Aminopyrimidines and Derivatives. 271.-Synthesis,Anticancer and Antimicrobiological Activities of 7-Glycopyranosyl-Pyrrolo[2,3-D]Pyrimidines2 |
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| Authors: | M L Quijano M Nogueras M Melguizo G Alvarez de Cienfuegos M Melgarejo A Sánchez |
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| Institution: | Deptos. Química Orgánica y Microbiologia , Colegio Universitario de Jaén Universidad de Granada , 23071, Jaén, Spain |
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| Abstract: | Abstract Reaction between 4-(O-acetyl-β-D-glycopyranosylamino)-6-oxopyrimidines 1 and chloroacetaldehyde leads to the corresponding 7-glycopyranosyl-4-oxopyrrolo 2,3-d]pyrimidines 3 in moderate yields. The reaction of 1a yields also 4-glucopyranosylaminofuro2,3-d] pyrimidine 2. The anticancer and antimicrobiological activities of these products are noticed. |
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