The Synthesis and Antiviral Activity of (E)-5-(2-Nitrovinyl)uridine and (E)-5-(2-Nitrovinyl)-2′-deoxyuridine |
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| Authors: | R F Whale V Bou P L Coe R T Walker |
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| Institution: | 1. School of Chemistry, University of Birmingham , PO Box 363, Birmingham, B15 2TT;2. Departament de Quimica Organica , Martif 1, Franques, 1-11, E-08028, Barcelona, Spain |
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| Abstract: | Abstract The protection of the sugar moiety of a 5-formyluracil nucleoside with acid-labile protecting groups allows for the deprotection of the sugar of a subsequently formed nucleoside possessing a 5-nitrovinyl side-chain. The synthesis and antiviral activity of (E) -5-(2-nitrovinyl)-uridine and (E)-5-(2-nitrovinyl)-2′-deoxyuridine are reported. |
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