Preparation and Antiviral Activity of Several Deoxygenated Ribavirin and Tiazofurin Derivatives |
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| Authors: | Krishna Upadhya Jay Dare Ernst M. Schubert Gwendolyn N. Chmurny Bjarne Gabrielsen |
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| Affiliation: | 1. Pharm-Eco Laboratories , 2355 Chain Dr., Simi Valley, CA, 93065;2. Program Resources Inc. NCI-FCRF , P.O. Box B, Frederick, MD, 21701;3. US Army Medical Research Institute of Infectious Diseases , Fort Detrick, Frederickc, MD, 21701-5011 |
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| Abstract: | ![]()
Abstract Ribavirin and tiazofurin, two nucleosides of known antiviral activity, have been transformed by previously reported methods to yield several deoxy,epoxy, or dideoxy analogues. The deoxygenated derivatives were evaluated for antiviral activity against a host of DNA and RNA viruses; however, no significant in vitro activity was detected. |
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