Interactions of 5-(1-Pyrenyl)-10,15,20-tris(4-methylpyridinium)porphine with Double-Helix and Triple-Helix Nucleic Acids |
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| Authors: | Naoki Sugimoto Shu-ichi Nakano Misa Katoh Muneo Sasaki Shin-ichi Kugimiya |
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| Affiliation: | 1. Department of Chemistry , Faculty of Science, Konan University , 8-9-1 Okamoto, Higashinada-ku, Kobe , 658 , Japan;2. Faculty of Pharmaceutical Sciences, Nagoya City University , 3-1 Tanabe-douri, Mizuho-ku, Nagoya , 467 , Japan |
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| Abstract: | ![]()
Abstract 5-(1 -Pyrenyl)-10,15,20-tris(4-methylpyridinium)porphine (H2PTMPP) having a porphyrin ring and a pyrenyl substituent was synthesized. The compound H2PTMPP bound to poly(dA)?poly(dT) double helix and poly(dA)?2poly(dT) triple helix in different styles. The results of H2PTMPP binding to oligonucleotides, dA14?dT14 and dA14?2dT14, was also shown. |
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