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C-Nucleoside Analogues of Nicotinamide Mononucleotide (NMN) |
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| Authors: | Krzysztof W. Pankiewicz Marek M. Kabat Elzbieta Sochacka Lech Ciszewski Joanna Zeidler Kyoichi A. Watanabe |
| Affiliation: | Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division of Graduate School of Medical Sciences, Cornell University , New York, NY, 10021, U.S.A. |
| Abstract: | Abstract 5-(β-D-Ribofuranosyl)nicotinamide (lie) and 6-(β-D-ribo-furanosyDpicolinamide (IId) and their corresponding o-isomers (III) were synthesized from ribonolactone. The C-nucleoside lie was further converted to its 5′-monophosphate Up which is isosteric to NMN Ip). |
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