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Synthesis of Some 2-Alkylated-5-Aminoimidazoles Related to Intermediates in Purine Nucleotide de novo and Thiamine Biosynthesis |
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| Authors: | Grahame Mackenzie Hilary A. Wilson Robert W. Humble Fawzy Hewedi Gordon Shaw David Ewing |
| Affiliation: | 1. Hmberside College of Higher Education , Cottingham Road, Hull, HU6 7RT;2. School of Chemistry Technology , University of Bradford , Bradford, 807 IDP;3. Department of Chemistry , University of Hull , Hull, HU6 7RT |
| Abstract: | Abstract Routes to 2-alkylated-5-aminoimidazole nucleosides have been investigated in which the 2-substituent has up to 3 carbon atoms and capable of being interconverted into suitable oxy and 0x0 alkyl derivatives for use in enzyme inhibition and biochemical incorporation studies involving both purine nucleotide de novo and thiamine biosynthesis. |
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