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Characterization of GPI2A,a Potent Inhibitor of HIV-1 Gene Expression and Viral Replication |
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| Authors: | Michael I. Anazodo Elena Duta Horacio Salomon Albert D. Friesen Mark A. Wainberg Jim A. Wright |
| Affiliation: | 1. Manitoba Institute of Cell Biology, and Department of Biochemistry and Molecular Biology , University of Manitoba , Winnipeg, MB, R3E 0V9, CANADA;2. Genesys Pharma Inc. , Winnipeg, MB, R3P 1P4, CANADA;3. McGill AIDS Centre , 3755 Chemin Cote-Ste-Catherine Road, Montreal, Quebec, H3T 1E2, CANADA;4. Genesys Pharma Inc. , Winnipeg, MB, R3P 1P4, CANADA;5. Manitoba Institute of Cell Biology, and Department of Biochemistry and Molecular Biology , University of Manitoba , Winnipeg, MB, R3E 0V9, CANADA |
| Abstract: | Abstract Fully thioated antisense molecules are often cytotoxic and non-specitic in action. GPI2A is thioated at 7 base positions. GPI2A posses sequence-specific activity against HIV-1 gene expression and viral replication without sigdcant cytotoxicity. Partial thioation did not compromise its uptake, cellular distribution and nuclease resistance. |
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