Properties of Some Diuridine Phosphate Analogues |
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| Authors: | Bhisma K Patel James B Thomson Victor Jiménez Klaus Eckart Fritz Fxkstein |
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| Institution: | 1. Max-Planck-Institut für experimentelle Medizin , Hermann-Rein-Str.3, D-37075, G?ttingen, Germany;2. Genetic Engineering and Biotechnology Center , PO Box 6162, Havana, Cuba |
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| Abstract: | Abstract The hydrolytic stability of oligoribonucleotides containing 2′- amino nucleophile is due to poor leaving characteristic of 5′-nucleoside, replacement of 5′-leaving group by thio or amino results in considerable instability towards hydrolysis. |
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