Biosynthesis of the Naturally Occurring Nucleoside Antibiotics from Adenosine |
| |
| Authors: | Robert J. Suhadolnik Jeffery C. Hanvey Somchai Pornbanlualap Joseph M. Wu Kamal N. Tiwari Anna K. Hebbler |
| |
| Affiliation: | 1. Department of Biochemistry , Temple University School of Medicine , Philadelphia, Pennsylvania, 19140;2. Department of Chemistry , University of Alabama , Tuscaloosa, AL, 35486 |
| |
| Abstract: | ![]()
Abstract 9-β-D-Arabinofuranosyladenine (ara-A, l), first isolated from the culture filtrates of StreDtomyces antibioticus, has a broad spectrum of activity against DNA viruses in cell culture and is successfully used in therapy of herpes simplex encephalitis, neonatal herpes, herpes zoster and chronic myelogenous leukemia1. 2′-Chlorodeoxycoformycin (2′CldCF, 2), 2′-amino-Zt-deoxyadenosine (3) and nucleocidin (4) have been isolated from the culture medium of Fctinomadura and S. clavus, respectively. |
| |
| Keywords: | |
|
|
