Conjugated Antisense Oligonucleotides for Inhibition of Human Cytomegalovirus In Vitro |
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| Authors: | Zhaoda Zhang Jean A. Smith Adrienne P. Smyth Warren Eisenberg Alexandra Nichols Gregory S. Pari |
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| Affiliation: | Hybridon, Inc. , One Innovation Drive, Worcester, MA, 01605, U.S.A. |
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| Abstract: | ![]()
Abstract Several thiono triester containing oligonucleotide phosphorothioates linked with a lipophilic group have been synthesized. Some of these modified antisense oligonucleotides show potent anti-HCMV activity as well as improved cellular association and nuclease resistance. |
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