Cytotoxic cycloartane triterpenoids from the leaves of Markhamia stipulata var. canaense |
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| Institution: | 1. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam;2. Institute of Chemical Technology, Vietnam Academy of Science and Technology, 01 Mac Dinh Chi, Ho Chi Minh city, Vietnam;3. Institute of Tropical Biology, Vietnam Academy of Science and Technology, 85 Tran Quoc Toan, Ho Chi Minh city, Vietnam;4. Tay Do University, 68 Lo Hau Thanh My, Can Tho city, Vietnam;5. Kien Giang University, 320A QL 61, Kien Giang city, Vietnam;1. National and Local Union Engineering Research Center of Veterinary Herbal Medicine Resources and Initiative, Hunan Agricultural University, Changsha, 410128, China;2. School of pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;3. Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China;1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China;2. Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, Nanning 530022, PR China;3. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China;1. Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China;2. Key Laboratory of Modern Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China;1. Department of Biochemistry, Isfahan University of Medical Sciences, Isfahan, Iran;2. Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran;3. Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;4. Dipartimento di Agraria, Università di Napoli Federico II, Portici, Napoli, Italy |
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| Abstract: | From the most cytotoxic fraction of the ethyl acetate extract of Markhamia stipulata var. canaense V.S. Dang leaves, two new cycloartane-type triterpenoids, named Markhacanasin A (1) and Markhacanasin B (2); were isolated by various chromatographic methods Their structures were elucidated by IR, UV, HR-ESI–MS, NMR (1D & 2D) experiments. The cytotoxicity of two new compounds against five human cancer cell lines (HeLa, HepG2, MCF-7, Jurkat and NCI-H460) were evaluated by SRB assay. As results, 1 exhibited significant cytotoxic activity against all cancer cell lines (IC50 ranged from 14.72 to 29.55 μM) while 2 did not show activity. |
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| Keywords: | Bignoniaceae Markhacanasin A Markhacanasin B |
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