Bioactive caffeic acid derivatives from Wedelia trilobata |
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| Institution: | 1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;2. Guangdong Provincial Key Laboratory of Bio-Control for the Forest Disease and Pest, Guangdong Academy of Forestry, Guangzhou 510520, China;3. Shaanxi Academy of Traditional Chinese Medicine, Xian 710003, China;4. College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China;1. College of Pharmacy, Guizhou University, Guiyang 550025, Guizhou, PR China;2. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, PR China;3. The Key Laboratory of Chemistry for Natural Products of Guizhou Medical University, Guiyang 550002, Guizhou, PR China;4. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, Hainan, PR China;1. Faculty of Science, Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon;2. Service Commun d’Analyses, Institut de Chimie Moléculaire de Reims (ICMR), CNRS UMR 7312, Bat. 18 B.P. 1039, 51687 Reims Cedex 2, France;3. Groupe Isolement et Structure, Institut de Chimie Moléculaire de Reims (ICMR), CNRS UMR 7312, Bat. 18 B.P. 1039, 51687 Reims Cedex 2, France;1. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming, PR China;2. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Nature Products, Kunming, PR China;1. Department of Biological Education, Faculty of Ahmet Kelesoglu Education, University of Necmettin Erbakan, Konya, Turkey;2. Department of Biology, Faculty of Science, Selcuk University, Konya, Turkey;3. Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, Chieti, Italy;4. Department of Health Sciences, Faculty of Science, University of Mauritius, Mauritius;1. Guangdong Provincial Key Laboratory of Applied Botany, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;2. State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources /Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China;3. College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China;4. University of Chinese Academy of Sciences, Beijing 100049, China;1. School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, PR China;2. The Provincial Education Key Laboratory of Screening, Evaluation and Advanced Processing of Traditional Chinese Medicine and Tibetan Medicine, School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, PR China;3. Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China;4. Institute of Plant Protection, Gansu Academy of Agricultural Sciences, Lanzhou 730070, China |
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| Abstract: | Two new caffeic acid derivatives, p-hydroxyphenyl caffeate (1) and methyl 3-(7-methoxy-dihydrocaffeoyl)-5-caffeoyl quinate (2), were isolated from the whole plant of Wedelia trilobata, along with four known ones, neochlorogenic acid methyl ester (3), methyl 4,5-di-O-caffeoyl quinate (4), methyl 3,5-di-O-caffeoyl quinate (5) and chlorogenic acid methyl ester (6). Their structures were elucidated on the basis of detailed spectroscopic analysis. They were all isolated from plant W. trilobata for the first time. Compounds 1, 2, 4 and 5 showed significantly in vitro α-glucosidase inhibitory activity with IC50 values from 0.029 to 0.362 mM, which were more potent than the reference compound acarbose (IC50 0.410 mM). Compound 1 was further revealed to show interesting in vitro tyrosinase inhibitory activity (IC50 2.00 μM) much stronger than positive control kojic acid (IC50 12.55 μM). |
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| Keywords: | Asteraceae Cafeic acid Tyrosinase inhibitory activity |
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