New antioxidant C-geranylated flavonoids from the fruit peels of Paulownia catalpifolia T. Gong ex D.Y. Hong |
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| Institution: | 1. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, Shandong, China;2. Institute of Materia Medica, Shandong Academy of Medical Sciences, Key Laboratory for Biotech-Drugs Ministry of Health, Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Jinan 250062, Shandong, China;3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;1. Department of Chemistry, University of Nairobi, P. O. Box 30197-00100, Nairobi, Kenya;2. Department of Chemistry and Molecular Biology, University of Gothenburg, SE-40530, Gothenburg, Sweden;3. Sahlgrenska Cancer Centre, University of Gothenburg, SE-405 30 Gothenburg, Sweden;4. Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111, Australia;5. Institut für Chemie, Universität Potsdam, Karl-Liebknecht-Str. 24-25, D-14476 Potsdam, Germany;6. Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada;7. Swedish NMR Center, University of Gothenburg, P.O. Box 465, SE-40530, Gothenburg, Sweden;1. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022, Vladivostok, Russian Federation;2. Far Eastern Federal University, 8 Sukhanova St., 690090, Vladivostok, Russian Federation;3. Botanical Garden-Institute Far Eastern Branch of the Russian Academy of Sciences, Makovskii Str. 142, 690024, Vladivostok, Russian Federation;4. Laboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, PR China;2. Research and Development Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming 650231, PR China;3. Clinical Laboratory, First People’s Hospital of Yunnan Province, Kunming 650032, PR China;1. Department of Chemistry, Inorganic Chemistry Section, Jadavpur University, Kolkata 700 032, India;2. Departamento de Química Inorgánica, c/ Francisco Tomás y Valiente, 7, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain;1. Chulabhorn Research Institute, Kamphaeng Phet 6, Talat Bang Khen, Lak Si, Bangkok 10210, Thailand;2. Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand |
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| Abstract: | Three new geranylated flavonoids, including two geranylflavones (1, 2) and one geranylflavonol (3), named as paucatalinone C–E, were isolated from the fruit peel of P. catalpifolia T. Gong ex D.Y. Hong. Their structures were determined by means of UV, IR, MS, and NMR techniques. To our known, geranylflavone or geranylflavonol was the first isolation from the genus Paulownia. These isolated geranylated flavonoids displayed good antioxidant effects on DPPH and the senescent human embryonic lung diploid fibroblasts cells (2BS cells) induced by H2O2. The geranyl substituent may be an important factor for the cellular radical-scavenging effect because of its lipophilic character. |
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| Keywords: | Geranylated flavonoids Antioxidant effects DPPH 2BS cells |
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