Phenylpropanoid amides from Alisma orientalis and their protective effects against H2O2-induced damage in SH-SY5Y cells |
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| Institution: | 1. College of Bioengineering, Beijing Polytechnic, Beijing 100029, China;2. Dalian Medical University, Dalian 116044, China;3. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;4. The Second Affiliated Hospital of Dalian Medical University, Dalian 116044, China;1. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022, Vladivostok, Russian Federation;2. Far Eastern Federal University, 8 Sukhanova St., 690090, Vladivostok, Russian Federation;3. Botanical Garden-Institute Far Eastern Branch of the Russian Academy of Sciences, Makovskii Str. 142, 690024, Vladivostok, Russian Federation;4. Laboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;1. College of Chemical Engineering, Huaqiao University, Xiamen 361021, China;2. Fujian Provincial Key Laboratory of Biochemical Technology (Huaqiao University), Xiamen 361021, China;1. School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, China;2. Medical Research Center, People''s Hospital of Longhua, Shenzhen 518000, China;1. Pharmacognosie et Molécules Naturelles Bioactives, Laboratoire d’Innovation Thérapeutique, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, F-67401 Illkirch Cedex, France;2. Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Faculté de Sciences, Université de Yaoundé, BP 812, Yaoundé, Cameroon;3. Chimie-Biologie Intégrative, Laboratoire d’Innovation Thérapeutique, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, F-67401 Illkirch Cedex, France;4. Service Commun d’Analyse, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, F-67401 Illkirch Cedex, France;5. Laboratoire de Chimie Thérapeutique, UMR 6229, 51 rue Congnacq-Jay, 51100 Reims, France |
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| Abstract: | Five new phenylpropanoid amides, including N-trans-feruloyl-N′-cis-feruloyl-cadaverine (1), N,N′-trans-diferuloyl-3-oxo-cadaverine (2), N-trans-feruloyl-N′-cis-feruloyl-3-hydroxy-cadaverine (3), N,N′-cis-diferuloyl-3-hydroxy-cadaverine (4), N-trans-p-coumaroyl-N′-trans-feruloyl-3-hydroxy-cadaverine (5), were isolated from Alisma orientalis together with four known analogues. Their structural elucidations were conducted by using 1D and 2D NMR and HRESIMS spectroscopic analyses. The isolated compounds were assayed for their inhibitory activities against HCE-2, anti-oxidant effects, and their protective effects on H2O2-induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y). Compounds 3, 6, and 7 displayed moderate anti-oxidant activities with IC50 values in the range of 36.9–40.7 μM. Compound 5 showed significant protective activity, while compounds 1, 2, 4, 7, and 8 showed moderate protective activities. |
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| Keywords: | Alkaloid Phenylpropanoid amide Protective activity |
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