核移植胚胎干细胞的研究及其应用前景

随着核移植技术和干细胞技术的逐渐成熟，目前已获得牛、小鼠核移植胚胎干细胞，以及人 - 兔异种间核移植胚胎干细胞，这些细胞在体外可分化成多种细胞形态 . 已经进行的实验性动物克隆性治疗，显示了诱人的潜力，但人核移植胚胎干细胞研究还面临着许多问题，如建系效率低、卵母细胞来源有限以及伦理学和安全性问题等 . 长远地看，随着克隆效率的提高，在道德与法律之间达成共识，核移植胚胎干细胞必将造福人类 .

Development of Nuclear-transfered Embryonic Stem Cells

With the development of the technique of nuclear transplantation, nuclear-transfered embryonic stem cell line of cattle, mice and human-rabbit inter-species now have produced. Although experimented therapeutic cloning in animal showed potentially clinical applications in human being, research of human nuclear-transfered embryonic stem cell is confronted with many problems, such as low efficiency of production of nuclear-transfered embryonic stem cell lines, the limited derivation of oocytes, dispute of ethic and politics, therapeutic security and etc. In the long run, the efforts should be focused on the development of cloning efficiency and the solution of ethical and politics concerns with scientific and idealistic progress. Nuclear-transfered embryonic stem cells will meet the high expectations of human for rejuvenation of the aging or diseased body.