Impact of exogenous sequences on the characteristics of an epidemic type 2 recombinant vaccine-derived poliovirus |
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Authors: | Riquet Franck B Blanchard Claire Jegouic Sophie Balanant Jean Guillot Sophie Vibet Marie-Anne Rakoto-Andrianarivelo Mala Delpeyroux Francis |
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Institution: | Unité de Biologie des Virus Entériques, Institut Pasteur, Paris, France. |
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Abstract: | Pathogenic circulating vaccine-derived polioviruses (cVDPVs) have become a major obstacle to the successful completion of the global polio eradication program. Most cVDPVs are recombinant between the oral poliovirus vaccine (OPV) and human enterovirus species C (HEV-C). To study the role of HEV-C sequences in the phenotype of cVDPVs, we generated a series of recombinants between a Madagascar cVDPV isolate and its parental OPV type 2 strain. Results indicated that the HEV-C sequences present in this cVDPV contribute to its characteristics, including pathogenicity, suggesting that interspecific recombination contributes to the phenotypic biodiversity of polioviruses and may favor the emergence of cVDPVs. |
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