Carbonic Anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry

A series of benzofused sultams and fluorinated benzenesulfonamides were synthesized in superacid HF/SbF₅ from simple N-allylic derivatives. Almost all of these original compounds showed micromolar inhibitory activities against carbonic anhydrases I and II. The fluorinated derivatives inhibit better the tumor-associated isoforms IX and XII, and one of the tested compounds showed inhibition in the nanomolar range.