Synthesis of Cell Coat in Normal and Transformed Cells |
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Authors: | LIVIO MALLUCCI G. H. POSTE VALERIE WELLS |
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Affiliation: | 1.Department of Virology,Royal Postgraduate Medical School,London |
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Abstract: | THE surface of transformed cells has been a focus of considerable attention recently because some of the properties which distinguish these cells from their precursors, such as decreased cell adhesiveness, altered cell orientation and loss of contact and density dependent inhibition1–3, may relate to changes on their surface. A common feature of vertebrate cells is the cell coat, a glycoprotein structure surrounding the plasma membrane4. Electron microscopy has revealed that transformed cells have a thicker coat than normal cells5 and we have now found that coat synthesis in cells transformed by an oncogenic DNA virus and in cells transformed by a chemical carcinogen occurs faster than in normal controls whereas only in the virus-transformed cells is the coat significantly thicker. |
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