It’s a knockout: CCN3 suppresses neointimal thickening |
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| Authors: | Andrew Leask |
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| Institution: | 1.CIHR Group in Skeletal Development and Remodeling, Division of Oral Biology, Department of Dentistry, Schulich School of Medicine and Dentistry, Dental Sciences Building,University of Western Ontario,London,Canada |
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| Abstract: | The role of CCN proteins in vivo is only just becoming understood. A prototypical member of the CCN family, CCN3 suppresses proliferation. In a study in press, Shimoyama and colleagues show that mice lacking CCN3 have a hyperproliferative response to vascular injury. These data, along with other recent observations, suggest that CCN3 may represent a novel therapy for hyperproliferative diseases. |
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| Keywords: | CCN3 Nov Hyperplasia Vasculature Injury |
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