Factors affecting the accuracy of urine-based biomarkers of BSE |
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| Authors: | Margot Plews Lise Lamoureux Sharon LR Simon Catherine Graham Viola Ruddat Stefanie Czub J David Knox |
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| Institution: | (1) Prion Diseases Program, Public Health Agency of Canada, Winnipeg, R3E 3P6, Canada;(2) Animal Diseases Research Institute, Canadian Food Inspection Agency, Lethbridge, T1J 3Z4, Canada;(3) GE Healthcare, San Francisco, CA 94110, USA;(4) Dept. of Medical Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada |
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| Abstract: | Background Transmissible spongiform encephalopathy diseases are untreatable, uniformly fatal degenerative syndromes of the central nervous
system that can be transmitted both within as well as between species. The bovine spongiform encephalopathy (BSE) epidemic
and the emergence of a new human variant of Creutzfeldt-Jakob disease (vCJD), have profoundly influenced beef production processes
as well as blood donation and surgical procedures. Simple, robust and cost effective diagnostic screening and surveillance
tools are needed for both the preclinical and clinical stages of TSE disease in order to minimize both the economic costs
and zoonotic risk of BSE and to further reduce the risk of secondary vCJD. |
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