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Effect of food-deprivation on rat pancreatic islet cells |
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| Authors: | Gregory Aponte Douglas Gross Grace Rosenquist Verne Mendel Tadataka Yamada |
| Affiliation: | a Department of Animal Science, School of Agriculture, University of California, Davis, CA 95616, USA b Department of Human Anatomy School of Medicine, and Department of Animal Psychology, University of California, Davis, CA 95616, USA c Center for Ulcer Research and Education, Department of Medicine and Research VA Wadsworth and UCLA Medical Centers, Los Angeles, CA 90073, USA |
| Abstract: | Somatostatin, insulin and glucagon concentrations in rat pancreas were measured following various intervals of food-deprivation. Tissue concentrations, as measured by radioimmunoassay, were correlated with A-, B-, and D-cell number and size using a scanning integrating image analyzer (Quantimet 720). Alterations in total islet hormone content were not correlated to changes in size or distribution of cells. This implies that changes in tissue content reflect changes in turnover of peptides rather than changes in cell size or number. |
| Keywords: | Pancreatic islets Food-deprivation Islet hormones Islet morphology Image analysis |
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