Molecular biology of Philadelphia chromosome in chronic granulocytic leukaemia and acute lymphoblastic leukaemia |
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Authors: | S Eridani L M Wiedemann L C Chan R G Dalton K K Karhi |
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Institution: | (1) Division of Haematology, United Medical Schools of Guy's, St Thomas' Campus, SE1 7EH London, UK;(2) Division of Haematology, St Thomas's Hospitals, St Thomas' Campus, SE1 7EH London, UK;(3) Leukaemia Research Fund Centre, Institute of Cancer Research, SW3 6JB London, UK |
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Abstract: | In classical t(9;22) translocation, as observed in chronic granulocytic leukemia (CGL), a hybrid DNA unit is produced, including a rearranged PHL gene, previously known as bcr (breakpoint cluster region) plus the translocated c-abl gene from chromosome 9: a hybrid bcr-abl protein, p210 is formed, with increased tyrosine kinase activity. Such DNA rearrangement, with a p210 protein synthesis, is also found in cases of Philadelphia-positive acute lymphoblastic leukemia (ALL), but in apparently similar cases the bcr gene is not rearranged, and a novel p190 abl-related protein can be found; c-abl rearrangement has also been observed.It is thus established that correlations between cytogenetic and molecular events can be found in CGL and ALL, as in other haemopoietic malignancies: translocation and possible rearrangement of the c-abl oncogene seem of particular importance in this case. |
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Keywords: | acute lymphoblastic leukemia Philadelphia chromosome abl proto oncogene p190 abl protein |
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