Sequence, structure and evolutionary relationships between class 2 aminoacyl-tRNA synthetases: An update |
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Authors: | S Cusack |
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Abstract: | The seven class 2 aminoacyl-tRNA synthetases that are α2 dimers have previously been divided by sequence homology into class 2a (seryl-, threonyl-, prolyl- and histidyl-) and class 2b (aspartyl-, asparaginyl- and lysyl-). It has been more difficult to classify the glycyl-, phenylalanyl- and alanyl-tRNA synthetases which have different subunit stoichiometries and which did not apparently contain all three canonical class 2 motifs. New sequence and structural information relating to the three problematic synthetases will be discussed permitting a step forward to be taken in the understanding of the evolutionary relationships between the class 2 synthetases. |
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Keywords: | class 2 aminoacyl-tRNA synthetase α 2 dimer |
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