Electrical bursting and luminal calcium oscillation in excitable cell models |
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Authors: | Teresa Ree Chay |
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Institution: | (1) Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA, US |
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Abstract: | It is shown in this paper that electrical bursting and the oscillations in the intracellular calcium concentration, Ca2+]i, observed in excitable cells such as pancreatic β-cells and R-15 cells of the mollusk Aplysia may be driven by a slow oscillation of the calcium concentration in the lumen of the endoplasmic reticulum, Ca2+]lum. This hypothesis follows from the inclusion of the dynamic changes of Ca2+]lum in the Chay bursting model. This extended model provides answers to some puzzling phenomena, such as why isolated single
pancreatic β-cells burst with a low frequency while intact β-cells in an islet burst with a much higher frequency. Verification
of the model prediction that Ca2+]lum is a primary oscillator which drives electrical bursting and Ca2+]i oscillations in these cells awaits experimental testing. Experiments using fluorescent dyes such as mag-fura-2-AM or aequorin
could provide relevant information.
Received: 17 August 1995/Accepted in revised form: 10 July 1996 |
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