Preclinical mouse model of optical coherence tomography for subcortical brain imaging without dissection |
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Authors: | Jae Meen Lee Inho Han Kyoung Hyup Nam Dong Hwan Kim Seunghwan Song Heejeong Park Hongki Kim Minkyu Kim Jeonghun Choi Jae Il Lee |
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Institution: | 1. Department of Neurosurgery, Medical Research Institute, Pusan National University Hospital, Busan, South Korea;2. Department of Thoracic and Cardiovascular Surgery, Medical Research Institute, Pusan National University Hospital, Busan, South Korea;3. Kohyoung Technology, Inc, Seoul, South Korea |
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Abstract: | The purpose of this study was to investigate the feasibility of using optical coherence tomography (OCT) to identify internal brain lesions, specifically intracerebral hemorrhage, without dissection. Mice with artificially injected brain hematomas were used to test the OCT system, and the recorded images were compared with microscopic images of the same mouse brains after hematoxylin and eosin staining. The intracranial structures surrounding the hematomas were clearly visualized by the OCT system without dissection. These images reflect the ability of OCT to determine the extent of a lesion in several planes. OCT is a useful technology, and these findings could be used as a starting point for future research in intraoperative imaging. |
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Keywords: | brain intracerebral hematoma neurosurgery optical coherence tomography |
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