Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets |
| |
| Authors: | Chong Huang Siavash Mazdeyasna Mehrana Mohtasebi Kathryn E Saatman Qiang Cheng Guoqiang Yu Lei Chen |
| |
| Institution: | 1. Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky, USA;2. Department of Physiology, Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky, USA;3. Division of Biomedical Informatics, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky, USA |
| |
| Abstract: | We adapted and tested an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) system for 3D imaging of cerebral blood flow (CBF) variations in perinatal disease models utilizing neonatal piglets, which closely resemble human neonates. CBF variations were concurrently measured by the scDCT and an established diffuse correlation spectroscopy (DCS) during global ischemia, intraventricular hemorrhage, and asphyxia; significant correlations were observed. Moreover, CBF variations associated reasonably with vital pathophysiological changes. In contrast to DCS measurements of mixed signals from local scalp, skull and brain, scDCT generates 3D images of CBF distributions at prescribed depths within the head, thus enabling specific determination of regional cerebral ischemia. With further optimization and validation in animals and human neonates, scDCT has the potential to be a noninvasive imaging tool for both basic neuroscience research in laboratories and clinical applications in neonatal intensive care units. |
| |
| Keywords: | cerebral blood flow neonatal piglet optical imaging perinatal disease |
|
|
