|
|||||
|
|
Effects of penicillin and erythromycin on adherence of invasive and noninvasive isolates of Streptococcus pyogenes to laminin |
|
| Authors: | Aleksandra ?mitran Dragana Vukovi? Ina Gaji? Jelena Marinkovi? Lazar Ranin |
| Affiliation: | 1.University of Banja Luka, Faculty of Medicine, Department of Microbiology and Immunology, Banja Luka, Republic of Srpska, Bosnia and Herzegovina;2.University of Belgrade, Faculty of Medicine, Institute of Microbiology and Immunology, Belgrade, Serbia;3.University of Belgrade, Faculty of Medicine, Institute of Medical Statistics and Informatics, Belgrade, Serbia |
| Abstract: | This study investigated the possible relationship between the invasiveness of group AStreptococcus (GAS) strains and their abilities to adhere tolaminin and assessed the effects of subinhibitory concentrations of penicillin anderythromycin on the ability of GAS to adhere to laminin. The adherence of noninvasiveand highly invasive isolates of GAS to laminin was significantly higher than theadherence displayed by isolates of low invasiveness. Antibiotic treatment causedsignificant reductions in adherence to laminin in all three groups of strains.Penicillin was more successful in reducing the adherence abilities of the tested GASstrains than erythromycin. |
| Keywords: | Streptococcus pyogenes adherence laminin penicillin erythromycin |