毛韧革菌次生代谢产物研究进展

毛韧革菌Stereum hirsutum是属于红菇目Russulales韧革菌科Stereaceae的一种木生担子菌,在我国分布广泛。过去70余年间从毛韧革菌中发现了112种次生代谢产物,主要包括倍半萜类、甾醇类、苯甲酸酯类、苯丙氨酸衍生物以及一些杂环化合物。这些化合物被证明具有抗氧化、抗肥胖、治疗糖尿病以及广泛的抗菌、抗癌症等功效。本文对毛韧革菌中发现的各种化合物的研究情况进行了总结,讨论了目前研究的主要问题,并对其应用前景进行了展望。

A review of research on the secondary metabolites of Stereum hirsutum

Stereum hirsutum is a kind of wood-inhabiting basidiomycetes belonging to Stereaceae in Russulales and widely distributed in China. Over the past 70 years, 112 secondary metabolites have been identified from S. hirsutum, including sesquiterpenes, sterols, benzoates, phenylalanine derivatives, and some heterocyclic compounds. These compounds show various bioactivities, such as anti-oxidation, anti-obesity, anti-diabetes, anti-bacterium, anti-cancer and so on. In this paper, the research advances of various secondary metabolites of S. hirsutum are reviewed, and the main problems in current research are discussed and the application prospect of these metabolites is predicted.