Effect of selected hypotensive drugs on the rate of sodium outflow through lymphocyte cell membranes and sodium lymphocyte levels in patients with primary hypertension]

Sodium outflow rate through lymphocyte cell membranes was investigated in patients with primary hypertension with disturbed and normal sodium transport through these membranes during the treatment with hydrochlorothiazide, propranolol, clonidine or verapamil. It was found that hydrochlorothiazide increases total outflow rate of sodium ions through lymphocyte cell membranes and decreases its concentration in the lymphocytes but does not affect ouabain-dependent sodium outflow rate. It was also noted that verapamil increases total and ouabain-dependent sodium outflow rate through lymphocyte cellular membranes and decreases its lymphocyte levels.