Stimulation of guanylate cyclase activity by several fatty acids. |
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| Authors: | T Asakawa I Scheinbaum R Ho |
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| Affiliation: | Earl W. Sutherland Research Laboratories Department of Biochemistry, University of Miami School of Medicine, Miami, Florida 33152 USA. |
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| Abstract: | Guanylate cyclase of plasma membrane of isolated rat fat cells was activated 7 to 11 fold by oleic acid, linoleic acid, linolenic acid or arachidonic acid. The activation of the enzyme by linoleic acid or oleic acid was influenced by the concentration of enzyme protein and that of the fatty acid. At 158 μg/ml of enzyme protein, 0.6 mM linoleic acid produced maximal activation of 12 fold which was partially reversed by washing. Particulate guanylate cyclase of cerebral cortex and liver was also activated by linoleic acid. |
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| Keywords: | cyclic GMP guanosine 3′,5′-monophosphate cyclic AMP adenosine 3′,5′-monophosphate |
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