Follicular atresia in the prepubertal spiny mouse (<Emphasis Type="Italic">Acomys cahirinus</Emphasis>) ovary |
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Authors: | Monika Hu?as-Stasiak Antoni Gawron |
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Institution: | (1) Department of Comparative Anatomy and Anthropology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland |
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Abstract: | This study was designed to determine follicular atresia in the newborn and the prepubertal spiny mouse. We analyzed the processes
of follicle loss using classical markers of apoptosis (TUNEL reaction, active caspase-3) and autophagy (Lamp1). Numerous small
clear vacuoles and autophagosomes as well as strong Lamp1 staining were observed in dying oocytes of all follicle types, especially
of the primordial and primary ones. Active caspase 3 and the TUNEL reaction were detected only in the granulosa cells of large
secondary and antral follicles. The expression of apoptosis and autophagy markers was also changing during the prepubertal
period. Western blot analysis indicated that at the moment of birth, females undergo an increased rate of follicular atresia
mediated by autophagy, while apoptosis is the dominant form of ovarian atresia in consecutive postnatal days. On the basis
of these observations, we concluded that apoptosis and autophagy are involved in follicular atresia and these processes are
cell and developmental stage-specific. |
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Keywords: | |
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