The retinoblastoma protein and the regulation of cell cycling. |
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| Authors: | D Cobrinik S F Dowdy P W Hinds S Mittnacht R A Weinberg |
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| Affiliation: | Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts, Institute of Technology, Cambridge 02142-1479. |
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| Abstract: | Increasing attention has been focused on how the retinoblastoma (RB) protein regulates cell growth. Recent evidence indicates that it is a substrate for phosphorylation by cyclin-dependent kinase-cyclin complexes and suggests that this phosphorylation modulates the ability of this protein to regulate transit through the cell cycle, perhaps in its G1 phase. |
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