THE GAUCHER MOUSE: ADDITIONAL BIOCHEMICAL ALTERATIONS |
| |
| Authors: | M C Stephens A Bernatsky G Legler J N Kanfer |
| |
| Institution: | Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada, R3E OW3 |
| |
| Abstract: | Abstract— Additional biochemical alterations were observed in the Gaucher mouse. The activity of β-xylosidase in brain, spleen and liver was considerably decreased in this animal model and acid phosphatase in plasma was increased about 4-fold. The levels of the splenic hexosylceramides, glucosyl-ceramide, lactosylceramide, trihexosylceramide, globoside and hematoside were all increased in comparison with controls. Brain ganglioside content was examined and very few differences were noted; however, there was a tendency towards slight elevations for the monosialogangliosides and GD1a and lower values for GD1b and GT. |
| |
| Keywords: | |
|
|
