Tumour-related enzyme alterations in the clear cell type of human renal cell carcinoma identified by two-dimensional gel electrophoresis. |
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| Authors: | S Balabanov U Zimmermann C Protzel C Scharf K J Klebingat R Walther |
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| Affiliation: | Department of Medical Biochemistry and Molecularbiology, University of Greifswald, Germany. |
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| Abstract: | To identify tumour-related enzyme alterations we have used 2D-gels to analyse the proteome from dissected malignant and benign kidney areas from patients with clear-cell-type renal carcinoma. The expression of 12 proteins was diminished in tumour. Four proteins were characterized by mass spectrometry and were identified as enoyl-CoA hydratase, alpha-glycerol-3-phosphate dehydrogenase, aldehyde dehydrogenase 1 and aminoacylase-I. |
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