Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study

Authors:	Fleur E van de Geijn Manfred Wuhrer Maurice HJ Selman Sten P Willemsen Ya?l A de Man André M Deelder Johanna MW Hazes Radboud JEM Dolhain

Affiliation:	(1) Department of Rheumatology, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 50, Rotterdam, 3015, GE, The Netherlands;(2) Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, PB, 9503, The Netherlands;(3) Department of Biostatistics, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 50, Rotterdam, 3015, GE, The Netherlands

Abstract:	Introduction Improvement of rheumatoid arthritis (RA) during pregnancy has been causatively associated with increased galactosylation of immunoglobulin G (IgG) N-glycans. Since previous studies were small, did not include the postpartum flare and did not study sialylation, these issues were addressed in the present study.

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